Early-Stage Discoveries: Choline may protect next generation from Alzheimer’s

Choline, an essential nutrient, converts the inflammatory factor homocysteine into methionine, which is beneficial.

Doctors believe homocysteine is a nerve toxin that contributes to Alzheimer’s disease (AD). In the lab, mice with AD symptoms fed choline during gestation and lactation had offspring with better spacial memory than those born to mothers that did not receive choline.

The third-generation offspring also showed memory benefits even without choline supplements. Choline also suppressed microglia, an inflammatory immune cell that becomes overactive in AD.