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NAC, Acetyl L-Carnitine and SAMe may improve cognition

In this new, one-year study, people with mild cognitive impairment improved after taking several supplements. They included vitamin E, B-vitamins, 600 mg of NAC (n-acetyl l-cysteine), 500 mg of acetyl l-carnitine, and 400 mg SAMe per day. Half the 34 participants, average age 66, took a placebo for six months, then the entire group took the supplements for another six months. Cognitive impairment involves memory, orientation, judgment, problem solving, personal care and other functions. Testing for these functions every three months, doctors found that the nutrient group improved significantly while the placebo group did not change.

In a second quarterly test of executive function, participants were asked to draw a clock as accurately as possible; a common way doctors assess the progression of Alzheimer’s disease. During the placebo phase, performance declined, but in all nutrient phases, participants were able to maintain or improve performance of the clock-drawing task.

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