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Sytrinol: a combination of citrus polymethoxy flavones (PMF) and tocotrienols

What is Sytrinol?

Sytrinol is a proprietary combination of natural citrus flavonoids, called polymethoxylated flavones (PMFs), and palm tocotrienols (analogs of tocopherols) that help maintain cholesterol levels already in the healthy range, as well as support overall cardiovascular function.

Heart health — recent studies

  • Lowered total cholesterol by 20% to 30%
  • Lowered LDL “bad” cholesterol by 19% to 27%
  • Lowered triglycerides by 24% to 34%
  • Lowered “bad” apoliprotein B (Apo B) by 21%
  • HDL “good” cholesterol remained unchanged
  • Improved the LDL:HDL ratio by 29%   

What makes Sytrinol so effective?

Sytrinol works by different mechanisms to protect your cardiovascular system:
1. PMFs decrease Apo B, a structural protein needed for LDL synthesis.
2. PMFs reduce the synthesis of triglycerides by inhibiting the enzyme DGAT and increasing fatty acid oxidation.
3. The palm tocotrienols in Sytrinol inhibit HMG CoA reductase, an enzyme responsible for synthesis of cholesterol in the liver. These actions, in addition to antioxidant benefits, make Sytrinol one of the most effective, natural dietary supplements for maintaining healthy cholesterol.

Cholesterol and heart health

High cholesterol in the blood is a key risk factor for heart disease. Data recorded by the American Heart Association shows an alarming rate of high cholesterol levels among Americans.

Total cholesterol levels above 200 milligrams per deciliter (mg/dl) of blood is considered borderline high. Extremely high total cholesterol is 240 mg/dl and above, which puts you at risk for heart disease, liver failure and other health problems.

Cholesterol can’t dissolve in the blood. It has to be transported to and from the cells by carriers called lipoproteins. Low-density lipoprotein (LDL) is known as “bad” cholesterol. High-density lipoprotein (HDL) is known as “good” cholesterol. These two types of lipids, along with triglycerides and lipoprotein(a) cholesterol, make up your total cholesterol count.

When too much LDL (bad) cholesterol circulates in the blood, it can slowly build up on the inner walls of the arteries that feed the heart and brain. Together with other substances, it can form plaque—a thick, hard deposit that can narrow the arteries and make them less flexible. This condition is known as atherosclerosis. If a clot forms and blocks a narrowed artery, heart attack or stroke can result.

Triglyceride is a form of fat made in the body. Elevated triglycerides can be due to being overweight/obese, physical inactivity, cigarette smoking, excess alcohol consumption and a diet very high in carbs (60% or more of total calories). People with high triglycerides often have a high total cholesterol level, including a high LDL (bad) level and a low HDL (good) level.

Antioxidant benefits

PMFs and tocotrienols are among many natural, potent antioxidants that have been researched for decades. PMFs can help protect blood vessel linings and prevent the oxidation of LDL cholesterol, which can lead to cardiovascular diseases. Tocotrienols are members of the natural vitamin E family and are some of the most powerful antioxidants. They have been linked to reduced rates of oxidative damage as well as reduced incidence of chronic diseases such as heart disease and cancer.

Safety of Sytrinol

Toxicity studies have shown that Sytrinol is well tolerated, with no toxic effects following consumption of up to one percent of total dietary intake, or the equivalent of a 150-pound person consuming almost 14 grams per day—that’s nearly 50 times the recommended daily dosage of 300 mg per day.

Clinical studies of Sytrinol

To date, three main studies have been carried out to investigate Sytrinol’s effects on high cholesterol levels. The first study involved 60 participants with raised cholesterol levels. After taking 300 mg of Sytrinol each day for four weeks, the researchers found that the treatment lowered total cholesterol by 25%, “bad” LDL cholesterol by 19% and triglycerides by 24%.

In a second, smaller study, 10 subjects with elevated cholesterol levels showed improvement after four weeks of treatment with 300 mg of Sytrinol per day. In this study, Sytrinol therapy lowered total cholesterol levels by 20%, LDL cholesterol by 22%, apolipoprotein B (a component of LDL) by 21%, and triglycerides by 28%. Participants also had a significant 5% increase in apolipoprotein A1 an important structural protein of the “good” HDL cholesterol.

Researchers recently completed a third clinical trial — a 12-week placebo-controlled study involving 120 men and women with moderately elevated cholesterol levels. Compared to those in the placebo group, subjects taking Sytrinol had a 30% drop in total cholesterol, a 27% drop in LDL cholesterol, and a 34% drop in triglycerides. In addition, HDL levels increased by 4%, resulting in a significant 29% improvement in the LDL:HDL ratio. It should be noted that during clinical trials, Sytrinol worked independent of diet changes.

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