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The ideal level of intake is not known. The amounts found in many multivitamin supplements (20–25 mg) are more than adequate for most people.
Vitamin B2 deficiency can occur in alcoholics. Also, a deficiency may be more likely in people with cataracts26, 27 or sickle cell anemia.28 In developing countries, vitamin B2 deficiency has been found to be a risk factor for the development of preeclampsia in pregnant women.29 People with chronic fatigue syndrome may be deficient in vitamin B2.30
Riboflavin is the most commonly used supplement form of vitamin B2 and most clinical trials have used that form. The biologically active form of vitamin B2—riboflavin 5’-phosphate—is also commercially available, although most of it is converted into riboflavin in the intestine before being absorbed.31
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The information presented by Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2017.