B vitamins with omega-3s protect brain size
The brain shrinks with age and those with Alzheimer’s disease and other dementias have faster shrink rates. In this study, researchers measured omega-3 and B-vitamin levels in 168 older adults with mild cognitive impairment and greater chances of developing dementia. Participants had taken a placebo or a high-dose B-vitamin supplement containing 800 mcg folic acid, 500 mcg B12, and 20 mg B6 for two years.

In those who began the study with the lowest circulating levels of omega-3's -- less than 390 micromoles per liter (mmol/L) of blood—brain atrophy rates did not change. Those with the highest levels of omega-3 fatty acids—more than 590 mmol/L—had a 40 percent slower brain atrophy rate after taking B-vitamin supplements, compared to placebo. It appears B-vitamins work with omega-3s to preserve brain size, and may help delay or prevent dementia.

Reference: Am J Clin Nutr. 2015:102(1):215-21.
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