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You might be surprised to learn that several studies have examined the effects of arginine supplementation on various aspects of health and performance.
For example, arginine is the rate-limiting amino acid in the synthesis of nitric oxide (NO), a gaseous substance that causes blood vessels to dilate. It’s well known that increasing the bioavailability of NO improves vasodilation and blood pressure, but emerging evidence suggests exercise efficiency and performance may benefit as well.
In one study, healthy men performed two separate exercise cycle tests one hour after consuming either 6 grams of arginine or a placebo. Arginine supplementation reduced the amount of oxygen required to perform exercise (i.e. increased exercise efficiency). This means that individuals accomplished the same exercise load but with less energy expended. Arginine supplementation also increased time to exhaustion by 26% during high-intensity cycling.
Other work has shown that arginine supplementation may increase growth hormone (GH). When arginine is infused directly into a vein, GH levels increase dramatically. In fact, arginine infusion is used clinically as a diagnostic test when GH deficiency is suspected. The dose of oral arginine needed to increase GH levels appears to be at least 5 grams, with larger responses shown with 9 grams.
In a different study, a combination formula consisting of 7 grams of arginine, 1.5 grams of HMB, 7 grams of glutamine and 3 grams of taurine resulted in striking improvements in body composition. Compared to a control group who received a placebo, healthy young men who took these supplements during 12 weeks of heavy resistance training showed a 10-pound greater increase in lean body mass.
References:
J Appl Physiol. 2010 Aug 19.
J Clin Endocrinol Metab. 2008 Feb;93(2):584-90.
Growth Horm IGF Res. 2005 Apr;15(2):136-9. Epub 2005 Jan 26.
J Appl Physiol. 2006 Sep;101(3):848-52.
Med Sci Sports Exerc. 2009 Apr 3. [Epub ahead of print].
Dr. Jeff Volek is a registered dietitian and Full Professor in the Department of Human Sciences at The Ohio State University. He has published 270 articles examining health and performance effects of low-carbohydrate diets and other dietary supplements including seminal work on creatine, carnitine and whey protein.
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