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Coenzyme Q10 reduces statin toxicity, improves performance in aging and lowers chances for heart problems*
CoQ10 reduced statin toxicity
Statin drugs lower cholesterol but with possible harmful side effects. Testing the three most common statins, doctors found rat liver cells pre-treated with CoQ10 were less toxic than those not treated with CoQ10. Doctors said their work demonstrates that adding CoQ10 to statin treatment may help protect the liver and other cells from injury due to statin drugs.
Reference: Arh Hig Rada Toksikol. 2014 Mar 1;65(1):101-8.


CoQ10 improves performance in aging
CoQ10 helped older mice swim more efficiently, and reduced oxidative damage in the energy-producing proteins of the heart, liver, and skeletal muscle and, to a lesser degree, in brain-cell energy proteins. Doctors said this is the first study to use CoQ10 after age-related cognitive declines have begun.
Reference: Age Oct. 2013, Vol.35, No. 5, 1821-1834.


CoQ10 lowers chances for heart problems
Coenzyme Q10 occurs naturally in the body and is a lipid-protecting antioxidant. In heart disease, many people take statin drugs to lower cholesterol levels, but statins reduce the body’s production of CoQ10. Doctors said high oxidative stress levels and chronic inflammation contribute to heart disease.
In this study, 42 people with blockage in at least half of one major artery who were taking statins for at least one month took a placebo or 300 mg of CoQ10 per day. After 12 weeks, while there were no changes for placebo, levels of three of the most important antioxidant enzymes had increased significantly in the CoQ10 group, and two signs of inflammation had decreased. Both groups had started the study with low CoQ10 levels, and in the CoQ10 group, levels increased by a factor of five times within four weeks. There were no side effects and doctors concluded that for those with heart disease, CoQ10 is safe and may be an effective treatment for decreasing inflammation and protecting lipids when taking statins.
Reference: Nutrition Journal; 2013, Vol. 12, No. 142.


CoQ10 may lower oxidative stress
In multiple sclerosis, the immune system mistakenly attacks the protective sheath surrounding nerve fibers in the central nervous system, distorting nerve impulses to and from the brain, causing a wide range of neurologic symptoms. Early effects include decreased or double vision, tingling, numbness, fatigue, weakness, and balance problems, in intermittent episodes called relapsing-remitting multiple sclerosis, or RRMS. Higher levels of oxidative stress may contribute to the disorder. In this study, 45 people with RRMS took a placebo or 500 mg of CoQ10 per day. After 12 weeks, while there were no changes for placebo, researchers saw lower levels of oxidative stress and higher levels of antioxidant activity in the CoQ10 group.
Reference: International Journal of Neuroscience; Nov 2013, Vol. 123, No. 11, Pages 776-782.



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