5-MTHF boosts folate levels

Mothers’ folate levels are critical for avoiding neural tube birth defects in children, and a type of folate, L-5-methyltetrahydrofolate (commonly called “Methylfolate”), or 5-MTHF, may be more effective for boosting folate levels than folic acid supplements.

In this study, 142 Malaysian women took a placebo, 1 mg of folic acid, or 1.13 mg of 5-MTHF, per day. The two doses were equivalent to 2.27 micromoles of nutrients each.

After 12 weeks, women taking 5-MTHF had folate levels 30 percent higher in red blood cells, and in plasma, than those taking folic acid. Both groups also had about 16 percent lower levels of homocysteine, an inflammatory factor, compared to placebo.


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