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Quercetin and senolytic drugs

As normal cells age, they stop dividing, a condition called senescense, a major factor in aging and disease. Senolytic drugs selectively eliminate these dying cells.

In the lab, with naturally aging mice, doctors combined the senolytic drug, dasatinib, with the antioxidant quercetin, and found the combination prevented cell damage, delayed physical dysfunction, and extended lifespan.

In a second phase of the study, dasatinib plus quercetin selectively killed senescent cells and slowed deterioration in walking speed, endurance, and grip strength. Doctors said senolytics including quercetin may enhance lifespan in older people, cancer survivors, and in other senescence-related conditions.

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