Early-stage discoveries: Nicotinamide and melanoma

In the lab, nicotinamide (also known as vitamin B3) reduced the spread of cancerous skin (melanoma) cells, and increased programmed cell death of melanoma cells. Also, cellular lab studies found nicotinamide enhanced DNA repair, reduced immune suppression from ultraviolet light, and increased anti-inflammatory effects on the skin. DNA damage, reduced immune response, and inflammation are factors in developing melanomas. In another lab study, nicotinamide inhibited the ability of melanoma cells to establish blood vessels similar to non-malignant cells, slowing the spread of the cancer.

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