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People with major depressive disorder often don’t tolerate or respond well to anti-depressant drugs, and they also may have low levels of SAMe, doctors in one study said. Fifty-five people with major depressive disorder who were not responding well to anti-depressants added 800 mg of SAMe twice per day, or a placebo, while continuing to take serotonin reuptake inhibitor drugs. After six weeks, compared to placebo, twice as many people in the SAMe group had improved depressive symptoms or had gone into remission.
Doctors believe that SAMe helps synthesize nerve-signaling chemicals such as serotonin, norepinephrine and dopamine, which may help make anti-depressants more effective.
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