Vitamin D may improve PMS-related mood disorders in young women

Doctors wanted to see if vitamin D in high doses could reduce the intensity of premenstrual-syndrome (PMS) related mood disorders in young women severely deficient in vitamin D.

In the study, 158 women, aged 15 to 21, with severe PMS symptoms and vitamin D levels no higher than 10 nanograms per milliliter of blood (ng/mL), took a placebo or an initial dose of 200,000 IU of vitamin D followed by 25,000 IU every two weeks for four months. After one month, the vitamin D group reached normal vitamin D levels of 35 to 60 ng/mL, and remained there throughout the study. After four months, while there were no measureable improvements for placebo, anxiety scores decreased to 20 from 51; irritability scores to 70 from 130; crying easily to 30 from 41, and sadness scores to 31 from 51 for the vitamin D group. In a measure of “disturbed relationships,” scores improved to 70 from 150 before vitamin D. 

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