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Resveratrol and hesperetin may help reduce chances for diabetes and heart disease
In the first part of this study, doctors in the lab introduced trans-resveratrol and hesperetin into a cell culture and found these two nutrients triggered an enzymatic process that reduces the harmful effects of sugar on the body. Lemons and sweet oranges naturally contain the flavonoid hesperidin, which becomes hesperetin when ingested. Trans-resveratrol can be found in grapes, wine, and the roots of the Japanese knotweed plant.

In the second part of the study, 32 men and women, aged 18 to 80, who were overweight or obese, took high daily doses of trans-resveratrol and hesperetin, or a placebo. After eight weeks, those in the resveratrol-hesperetin group who had body-mass index scores of more than 27.5 saw increases in the enzymatic activity that protects the body from excess sugar. Also, doctors saw improved insulin activity, better artery function, and reduced inflammation in blood vessels. There were no changes for placebo.

Discussing the findings, doctors said trans-resveratrol with hesperetin may help reduce chances for diabetes and heart disease, particularly in those who are obese.


Reference: Diabetes Journals; 2016, db160153, Published Online.
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