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Managing depression
Some people with major depression do not respond well to the typical SSRI drug treatment. In this study, 26 men and women, aged 28 to 70, who had not responded well to SSRIs took 800 mg or 1,600 mg of SAMe per day.

After 15 weeks, participants on both doses had an average 35 percent improvement in symptoms. A group of eight who had not responded to SAMe then took 116 mg of magnesium. After eight weeks, seven saw significant clinical improvement in depression symptoms. Doctors believe these nutrients may help rebalance the gut, where the body produces much of the neurotransmitter serotonin.

Reference: Advances in Integrative Medicine; 2015, Vol. 2, No. 1, 56-62.
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