Glucosamine and chondroitin as effective as NSAID OA drug
Doctors were interested in the long term effects of glucosamine and chondroitin on severe osteoarthritis (OA) of the knee, compared to standard OA drugs. This study followed 606 participants from 42 European medical centers who took 500 mg of glucosamine hydrochloride plus 400 mg of chondroitin sulfate three times per day, or 200 mg of celecoxib per day.

For the first four months, the celecoxib group had better results, but by six months, both the celecoxib and glucosamine/chondroitin groups had similar recovery from pain, stiffness, joint swelling, and physical function, ranging from 45 to 50 percent improvement in all four measures. Researchers excluded from the study those with higher chances of heart disease or stomach problems, and participants reported no serious side effects from either treatment, which doctors said proved to be safe.

Reference: Annals of the Rheumatic Diseases; January, 2014, Published Online.
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