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Berberine and silymarin from milk thistle reduced cholesterol and blood sugar

Berberine (from barberry) and silymarin (from milk thistle) are plant-based compounds with immune enhancing properties.

In this review of five placebo-controlled trials covering 497 adults, participants took doses of 500 mg or 1,000 mg of berberine per day plus 105 mg or 210 mg of silymarin per day, in studies lasting from three to 12 months.

Overall, those taking the berberine-silymarin combinations saw average reductions in triglycerides of 28 mg per deciliter of blood (mg/dL); total cholesterol down by 25 mg, LDL cholesterol down by 29 mg, and an increase in HDL cholesterol of 6 mg/dL.

Long-term average blood sugar levels declined by 7.5 mg/dL. Doctors said combining berberine with silymarin can promote heart and metabolic health.

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