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Folic acid and hypertension
Earlier folic acid studies focused on preventing heart disease, but this is the first to examine its effect on stroke. Doctors wanted to test folic acid in those with high blood pressure; a factor that raises chances for stroke. In the study, 10,348 hypertensives who had not had a stroke or heart attack took 10 mg of enalapril; a standard blood-pressure medication, with or without 800 mcg of folic acid per day.

After 4.5 years of follow-up, those taking medication plus folic acid were 21 percent less likely to have had any kind of stroke compared to those who took blood pressure medicine alone. The folic acid group was also less likely to have had an ischemic stroke; where blood supply is cut off, and less likely to have had a heart attack or to have died from cardiovascular disease than those taking standard medication alone.

Reference: Journal of the American Medical Association; 2015, Vol. 313, No. 13: 1325-1355.
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