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Resveratrol and colitis
This is the first placebo-controlled trial to test the effects of resveratrol on oxidative stress levels in ulcerative colitis (UC), an inflammatory condition of ulcers or sores in the lining of the large intestine. While doctors don’t know the cause, they believe oxidative stress plays a role.

In this study, 56 people with active mild to moderate UC took a placebo or 500 mg of resveratrol per day. After six weeks, levels of the important antioxidant, superoxide dismutase (SOD), had decreased for placebo while increasing for resveratrol. Total antioxidant capacity and signs of oxidative stress deteriorated in the placebo group but improved for resveratrol.

While there were no improvements for placebo, measurements of disease activity decreased and quality of life test scores improved for those taking resveratrol. Doctors concluded resveratrol can reduce oxidative stress in those with ulcerative colitis, and improve quality of life.


Reference: Archives of Medical Research; 2016, Vol. 47, No. 4, 304-9.
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