Research suggests that in addition to creatine accumulation in skeletal muscle, the brain may also take up creatine. This study had healthy men and women load with 20 grams of creatine per day or placebo for one week.
After this supplementation period, subjects were tested intermittently over a 24-hour period that involved exercise and sleep deprivation on a variety of cognitive tests. At 24 hours, the group that supplemented with creatine had significantly better performance in respect to random movement generation, choice reaction time, balance, and mood state.
Thus, the results indicate that creatine supplementation would limit the negative effects of 24 hours of sleep deprivation on cognitive and psychomotor performance and mood state. Creatine not only aids muscles, it may also overcome brain fatigue.