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At least three different groups of constituents in bitter melon have been reported to have blood-sugar lowering actions of potential benefit in diabetes mellitus. These include a mixture of steroidal saponins known as charantin, insulin-like peptides, and alkaloids. It is still unclear which of these is most effective, or if all three work together. Some clinical trials have confirmed the benefit of bitter melon for people with diabetes.7
In traditional herbal medicine, bitter melon—like other bitter-tasting herbs—is thought to stimulate digestive function and improve appetite. This has yet to be tested in human studies.
For those with a taste or tolerance for bitter flavor, a small melon can be eaten as food, or up to 3 1/3 ounces (100 ml) of a decoction or 2 ounces (60 ml) of fresh juice can be drunk per day.8 Though still bitter, tinctures of bitter melon (1 teaspoon [5 ml] two to three times per day) are also sometimes used. The amounts recommended would be appropriate for people with diabetes.
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The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2016.