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Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.
For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.
| Supplement | Amount | Why |
|---|---|---|
Acetyl-L-Carnitine | 1 gram taken three times per day |  [2 stars] Short-term studies have found that people with Alzheimer’s disease who supplement with acetyl-L-carnitine experience improved memory, enhanced overall performance, and delayed disease progression. |
Ginkgo | 120 to 240 mg of a standardized herbal extract daily | [2 stars] Ginkgo biloba extract is an approved treatment for early-stage Alzheimer’s disease in Europe. It is thought to improve memory and quality of life and slow early disease progression.
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Huperzia | 200 mcg of huperzine A twice per day | [2 stars] Huperzine A, a substance found in the Chinese medicinal herb huperzia (Huperzia serrata), has been shown to improve memory and mental and behavioral function in people with dementia, including Alzheimer’s disease. |
Lemon Balm | 60 drops per day of a 1:1 herbal tincture, standardized to contain at least 500 mcg per ml of citral | [2 stars] Supplementing with an herbal extract of lemon balm (Melissa officinalis) has been shown to improve cognitive function and reduce agitation in people with Alzheimer's disease.
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Periwinkle | Refer to label instructions | [2 stars] Lesser periwinkle contains the alkaloid vincamine, which has shown some benefit to people with Alzheimer’s disease.
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Sage | 60 drops daily of a 1:1 tincture | [2 stars] Sage appears to have an effect on acetylcholine, one of the chemical messengers (neurotransmitters) in the brain and supplementing with sage has resulted in a significant improvement in cognitive function. |
Vitamin B1 | 3 grams daily | [2 stars] Supplementing with vitamin B1 might slow Alzheimer’s disease progression in people whose vitamin B1–dependent enzymes have low activity.
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Vitamin E | 2,000 IU daily | [2 stars] Antioxidant supplements such as vitamin E have been associated with lower risk of Alzheimer’s disease and improved brain function in middle-aged and older adults.
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Asian Ginseng | 4.5 grams per day for 12 weeks |  [1 star] A preliminary trial suggests that taking Panax ginseng may significantly improve a measure of cognitive function in the short term, though long-term use has not been established. |
Bacopa | Refer to label instructions | [1 star] Animal studies have found the Ayurvedic herb bacopa has constituents that enhance several aspects of mental function and learning ability. |
Coenzyme Q10, Iron, and Vitamin B6 | Refer to label instructions | [1 star] A combination of coenzyme Q10, iron (sodium ferrous citrate), and vitamin B6 may improve mental status in people with Alzheimer’s disease. |
DHEA | Refer to label instructions | [1 star] People with Alzheimer’s disease may have low DHEA (dehydroepiandrosterone) levels, and supplementation may improve mental performance.
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DMAE | Refer to label instructions | [1 star] DMAE (2-dimethylaminoethanol) may increase levels of a brain neurotransmitter, which may foster positive behavior changes in people with dementia. |
Fish Oil | Refer to label instructions | [1 star] Fish oil may help slow the rate of cognitive decline in people with very mild impairment.
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Folic Acid | Refer to label instructions | [1 star] Some researchers feel Alzheimer’s disease may be related to folic acid deficiency. |
Lecithin (Phosphatidyl Choline) | Refer to label instructions | [1 star] Weak evidence suggests that moderate amounts of lecithin, a fat used by the body to build membranes that may be obtained through food sources, may slightly improve symptoms.
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NADH | 10 mg per day | [1 star] A small, preliminary trial showed that oral NADH improved mental function in people with Alzheimer’s disease. |
Phosphatidylserine | Refer to label instructions | [1 star] There is some evidence that cow-derived PS (phosphatidylserine) has been shown to improve mental function and feelings of well-being in people with Alzheimer’s disease, though most research has not found benefit.
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Vitamin B12 | Refer to label instructions | [1 star] Some researchers feel Alzheimer’s disease may be related to vitamin B12 deficiency. |
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The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2014.
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Information provided on this site is solely for informational purposes only. It is not a substitute for professional medical advice. Do not use this information for diagnosing or treating a health problem or disease, or prescribing of any medications or supplements. Only your healthcare provider should diagnose your healthcare problems and prescribe treatment. None of our statements or information, including health claims, articles, advertising or product information have been evaluated or approved by the United States Food and Drug Administration (FDA). The products or ingredients referred to on this site are not intended to diagnose, treat, cure or prevent any disease. Please consult your healthcare provider before starting any supplement, diet or exercise program, before taking any medications or receiving treatment, particularly if you are currently under medical care. Make sure you carefully read all product labeling and packaging prior to use. If you have or suspect you may have a health problem, do not take any supplements without first consulting and obtaining the approval of your healthcare provider. California Consumers – Proposition 65 requires sellers to notify California consumers of substances that are in many foods, plants, herbs and supplements with the following warning. WARNING: These products contain chemicals known to the State of California to cause birth defects or other reproductive harm.
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