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Pycnogenol, an extract of the bark of the French maritime pine, contains a mixture of many substances belonging to the flavonoid family, primarily proanthocyanidins and phenolic acids. Test tube, animal, and preliminary human research has shown Pycnogenol to have antioxidant and anti-inflammatory activity through several biological mechanisms, as well as blood thinning, blood vessel relaxing, and connective tissue– strengthening effects.
This study included 98 people with severe chronic venous insufficiency symptoms, such as leg swelling, pain, and elevated leg vein pressure when standing and walking. Participants were randomly selected for one of the following groups:
Compared with the compression stockings only group, after eight weeks of treatment, ankle swelling (edema) and clinical symptoms such as pain and leg heaviness significantly decreased in the people using the Pycnogenol supplement plus compression stockings and in the Pycnogenol-only groups. Markers of lower leg blood circulation also significantly improved in the Pycnogenol groups.
This research suggests that even after severe chronic venous insufficiency has developed, a standardized, 150 mg Pycnogenol dietary supplement can improve symptoms and clinical signs of the disease. This should improve quality of life, and over the long term it may slow down the worsening of symptoms. Use the following tips on safe use of Pycnogenol, plus other steps you can take to better manage chronic venous insufficiency:
Suzanne Dixon, MPH, MS, RD, an author, speaker, and internationally recognized expert in chronic disease prevention, epidemiology, and nutrition, has taught medical, nursing, public health, and alternative medicine coursework. She has delivered over 150 invited lectures to health professionals and consumers and is the creator of a nutrition website acclaimed by the New York Times and Time magazine. Suzanne received her training in epidemiology and nutrition at the University of Michigan, School of Public Health at Ann Arbor.