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Researchers invited 73 adults with triglyceride levels between 200 and 500 mg per deciliter (dl) into a study on the effects of medication and omega-3 dietary fat supplements on high triglycerides. (A diagnosis of high triglycerides is defined as blood levels greater than 150 to 200 mg per dl.)
Participants were 30 to 70 years old, had normal cholesterol levels, and had never been treated for high triglycerides. They did not have serious conditions including diabetes, chronic inflammation, heart failure, unstable coronary artery disease, heart attack, stroke, or moderate to severe high blood pressure.
Study participants were randomly selected to take one of the following, twice daily, for 12 weeks:
Researchers collected blood samples to test for blood levels of glucose (before and after eating), triglycerides, and cholesterol. They also tested for three blood markers (fibrinogen, factor VII and PAI-1) that play a role in blood clotting and are associated with risk of accelerated progression of heart disease and its complications.
After 4 and 12 weeks of treatment, the researchers noted:
Both omega-3 fat supplements and the medication bezafibrate effectively reduced triglyceride levels, but only bezafibrate decreased cholesterol and blood sugar levels. This confirms previous research on triglycerides and points to considerations you should make when deciding how best to manage your triglyceride levels.
Study participants had isolated high triglycerides. They did not have high cholesterol, high blood sugar, or high levels of other heart disease risk factors. This means:
If your triglycerides are mildly elevated, you may not need a supplement or medication. Other ways to lower triglycerides include:
(Pharmacol Rep 2011;63:763–71)
Suzanne Dixon, MPH, MS, RD, an author, speaker, and internationally recognized expert in chronic disease prevention, epidemiology, and nutrition, has taught medical, nursing, public health, and alternative medicine coursework. She has delivered over 150 invited lectures to health professionals and consumers and is the creator of a nutrition website acclaimed by the New York Times and Time magazine. Suzanne received her training in epidemiology and nutrition at the University of Michigan, School of Public Health at Ann Arbor.