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Studying people with high cholesterol can shed light on how anthocyanins may work in people with higher-than-average heart disease risk. To study their effects on inflammation, researchers randomly selected 150 adults with high cholesterol to take 350 mg of anthocyanins or a placebo twice per day for 24 weeks. Neither the researchers nor the study participants knew who was assigned to the anthocyanin group.
Participants were asked to avoid consuming foods and drinks high in anthocyanins for the duration of the study (high-anthocyanin food list was provided), but otherwise maintain their usual diet and lifestyle habits. Blood samples were collected at the start of the study and at 12 and 24 weeks.
Compared with the placebo group, substances in the blood that signal inflammation and that are associated with higher heart disease risk were significantly lower in the anthocyanin group:
Additionally, HDL, (“good” cholesterol) increased by an average of 14% in the anthocyanin group.
The study showed that anthocyanin supplements improve markers of heart disease risk, but it did not consider how anthocyanins affect heart disease itself—the researchers didn’t follow participants long enough to see how the supplement might affect risk of heart attack, for example. Still, the results suggest that anthocyanins may enhance cardiovascular health, particularly in people with high cholesterol. Our tips can help you develop a heart healthy plan, with or without anthocyanin supplements.
(In press: Nutr Metab Cardio Dis 2012, doi: dx.doi.org/10.1016/ j.numecd.2012.06.005)