Heath Notes

Greater Celandine

Botanical name: Chelidonium majus

Parts used and where grown

Greater celandine grows primarily in Europe and Asia, although it has been introduced in North America. The leaves and small yellow flowers of greater celandine are used as medicine. Although the roots and rhizomes of the plant have also been used medicinally, most clinical trials have used the above-ground parts of the plant collected at the time of flowering.¹

Greater celandine has been used in connection with the following conditions (refer to the individual health concern for complete information):

Science Ratings	Health Concerns
	Indigestion
	Biliary dyskinesia Cholecystitis Warts
Reliable and relatively consistent scientific data showing a substantial health benefit. Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit. For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support and/or minimal health benefit.

Science Ratings

Health Concerns

Indigestion

Biliary dyskinesia

Cholecystitis

Warts

Reliable and relatively consistent scientific data showing a substantial health benefit.
2Stars

Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
1Star

For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support and/or minimal health benefit.

Historical or traditional use (may or may not be supported by scientific studies)

European herbal traditions regard greater celandine as a valuable remedy for the topical treatment of warts.² It was also a folk remedy for cancer, gout, jaundice, and a variety of skin diseases. The famous French herbalist Maurice Mességué used greater celandine extensively in hand and foot baths and teas for many conditions, particularly those affecting the liver.³ In eastern Asia it was also valued as a treatment for peptic ulcer.⁴

Active constituents

Greater celandine, like other members of the Papaveraceae (poppy) family, contains alkaloids as its major constituents. These include chelidoxanthine, chelidonine, and coptisine. Greater celandine extracts have been shown to stimulate production of bile and pancreatic digestive enzymes in human studies.⁵

Animal and test tube studies have shown that the alkaloids and whole plant extract can relieve gallbladder spasms and stimulate an under-active gallbladder.⁶ ⁷ Test tube and animal studies have also shown celandine extracts and purified alkaloids to have anti-inflammatory, anti-cancer and antimicrobial properties.⁸ ⁹ ¹⁰ They have also shown greater celandine’s ability to protect animal livers from toxic substances.¹¹ ¹²

A double-blind trial found that a standardized extract of greater celandine could relieve symptoms of indigestion (such as abdominal cramping, sensation of fullness, and nausea) significantly better than a placebo.¹³ The trial used an extract standardized to 4 mg of chelidonine per capsule and gave 1–2 tablets three times daily for six weeks. An earlier, preliminary trial also found the same extract reduced symptoms in people with indigestion.¹⁴

Preliminary reports from Russia and China have reported that a tincture of greater celandine applied topically was useful for warts.¹⁵ However, these results have not yet been confirmed by double-blind clinical trials.

Several reports describe Eastern European clinical trials using semi-synthetic derivatives of greater celandine alkaloids for people with cancer.¹⁶ This injectable product goes by the name Ukrain®. The findings on this drug cannot be applied to greater celandine because the alkaloids have been modified from their original form.

How much is usually taken?

One explanation for the variable results obtained from using greater celandine is improperly prepared, dried extracts.¹⁷ Drying extracts quickly at high temperature is necessary to preserve the alkaloids.¹⁸ Extracts standardized to a content of 4 mg chelidonine per capsule are recommended to be taken three times per day.¹⁹ Alternatively, one may mix 1–3 ml tincture into water and sip slowly 10–30 minutes before eating. Topical applications should consist of either concentrated tinctures or the fresh yellow latex. Herbalists and doctors recommend applying fresh latex once per day to warts and allowing it to dry in place.²⁰

Are there any side effects or interactions?

Use of fresh plant products may cause stomach upset.²¹ Topical use has been associated with intense itching and a rash in one case.²² Greater celandine should be avoided during pregnancy and in children under age 12.²³ A recent report of ten women in Germany suffering from acute hepatitis following supplementation with a standardized extract of greater celandine (dosage was not given) suggest this herb should be avoided by people with hepatitis or impaired liver function. Greater celandine should be used cautiously and under the supervision of a healthcare professional until more is understood about its potential liver toxicity.²⁴

At the time of writing, there were no well-known drug interactions with greater celandine.

References
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1. Weiss RF. Herbal Medicine. Gothenburg, Sweden: Ab Arcanum and Beaconsfield, UK: Beaconsfield Publishers Ltd, 1985, 84–8.

2. Duke JA. CRC Handbook of Medicinal Herbs. Boca Raton, FL: CRC Press, 1985, 113.

3. Mességué M. Of Men and Plants. New York: Macmillian Co, 1973.

4. Duke JA. CRC Handbook of Medicinal Herbs. Boca Raton, FL: CRC Press, 1985, 113.

5. Baumann JC. Effect of Chelidonium, Curcuma, absinth and Carduus marianus on the bile and pancreatic secretion in liver diseases. Med Monatsschr 1975;29:173–80 [in German].

6. Hiller KO, Ghorbani M, Schilcher H. Antispasmodic and relaxant activity of chelidonine, protopine, coptisine, and Chelidonium majus extracts on isolated guinea-pig ileum. Planta Med 1998;64:758–60 [letter].

7. Hriscu A, Galesanu MR, Moisa L. Cholecystokinetic action of an alkaloid extract of Chelidonium majus. Rev Med Chir Soc Med Nat Lasi 1980;84:559–61 [in Romanian].

8. Vavreckova C, Gawlik I, Muller K. Benzophenanthridine alkaloids of Chelidonium majus; I. Inhibition of 5- and 12-lipoxygenase by a non-redox mechanism. Planta Med 1996;62:397–401.

9. Sokoloff B, Saelhof CC, Takeuchi Y, Powella R. The antitumor factors present in Chelidonium majus L. I. Chelidonine and protopine. Growth 1964;28:225–31.

10. Molochko VA, Lastochkina TM, Krylov IA, Brangulis KA. The antistaphylococcal properties of plant extracts in relation to their prospective use as therapeutic and prophylactic formulations for the skin. Vestn Dermatol Venerol 1990;(8):54–6 [in Russian].

11. Mitra S, Gole K, Samajdar K, et al. Antihepatotoxic activity of Chelidonium majus. Int J Pharmacognosy 1992;30:125–8.

12. Mitra S, Sur RK, Roy A, Mukherjee AS. Effect of Chelidonium majus L on experimental hepatic tissue injury. Phytother Res 1996;10:354–6.

13. Ritter R, Schatton WFH. Clinical trial on standardized celandine extract in patients with functional epigastric complaints: Results of placebo-controlled double-blind trial. Comp Ther Med 1993;1:189–93.

14. Kniebel R, Urlacher W. Z Allgemeinmed 1993;69:680–4.

15. Bone K (ed). Chelidonium--A medicinal poppy. MediHerb Professional Newsletter 1996;49:1–3.

16. Susak YM, Zemskov VS, Yaremchuk OY, et al. Comparison of chemotherapy and x-ray therapy with Ukrain monotherapy for colorectal cancer. Drugs Exptl Clin Res 1996;22:115–22.

17. Weiss RF. Herbal Medicine. Gothenburg, Sweden: Ab Arcanum and Beaconsfield, UK: Beaconsfield Publishers Ltd, 1985, 84–8.

18. Bone K (ed). Chelidonium--A medicinal poppy. MediHerb Professional Newsletter 1996;49:1–3.

19. Ritter R, Schatton WFH. Clinical trial on standardized celandine extract in patients with functional epigastric complaints: Results of placebo-controlled double-blind trial. Comp Ther Med 1993;1:189–93.

20. Weiss RF. Herbal Medicine. Gothenburg, Sweden: Ab Arcanum and Beaconsfield, UK: Beaconsfield Publishers Ltd, 1985, 84–8.

21. McGuffin M, Hobbs C, Upton R, Goldberg A (eds). American Herbal Products Association’s Botanical Safety Handbook. Boca Raton, FL: CRC Press, 1997.

22. Etxenagusia MA, Anda M, Gonzalez-Mahave I, et al. Contact dermatitis from Chelidonium majus (greater celandine). Contact Derm 2000;43:47.

23. McGuffin M, Hobbs C, Upton R, Goldberg A (eds). American Herbal Products Association’s Botanical Safety Handbook. Boca Raton, FL: CRC Press, 1997.

24. Benninger J, Schneider HT, Schuppan D, et al. Acute hepatitis induced by greater celandine (Chelidonium majus). Gastroenterol 1999;117:1234–7.

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The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires September 2008.