Glyburide Also indexed as: Diabeta, Glibenclamide, Glynase, Glynase Prestab, Micronase, Pres Tab
Glyburide is a sulfonylurea drug used to lower blood sugar levels in people with type 2 (non-insulin-dependent) diabetes. Maintaining normal blood sugar levels helps reduce health problems associated with diabetes. People with diabetes should consult with their doctor before starting or stopping any form of treatment including drug therapy, herbal products, supplements, and others.
Consumption of a high-fiber diet and/or supplementation with nutrients such as chromium, biotin, vitamin E, and others or herbs such as gymnema will often improve blood-sugar control in diabetics. In such cases, the amount of blood sugar-lowering drugs may need to be reduced in order to avoid a hypoglycemic reaction. Anyone taking medication for diabetes should consult the prescribing physician before making dietary changes or taking nutrients or herbs that are designed to lower blood-sugar levels.
Summary of Interactions with Vitamins, Herbs, and Foods
In some cases, an herb or supplement may appear in more than one category, which may seem contradictory. For clarification, read the full article for details about the summarized interactions.
 May Be Beneficial: Supportive interaction—Taking these supplements may support or otherwise help your medication work better. | Aloe* |
 Avoid: Adverse interaction—Avoid these supplements when taking this medication because taking them together may cause undesirable or dangerous results. | Ginkgo |
 Check: Other—Before taking any of these supplements or eating any of these foods with your medication, read this article in full for details. | Biotin Chromium Gymnema Vitamin E |
| Depletion or interference | None known |
| Side effect reduction/prevention | None known |
| Reduced drug absorption/bioavailability | None known |
An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
Interactions with Supps
Chromium
Chromium supplements have been shown to improve blood sugar control in people with diabetes.1 Consequently, supplementing with chromium could reduce blood sugar levels in people with taking glyburide, potentially resulting in abnormally low blood sugar levels (hypoglycemia). While chromium supplementation may be beneficial for people with diabetes, its use in combination with glyburide or with any other blood sugar-lowering medication should be supervised by a doctor.
Interactions with Herbs
Aloe (Aloe vera)
One single-blind study in Thailand reported that combining 1 Tbsp (15 ml) of aloe juice twice daily with glyburide significantly improved blood sugar and lipid levels in people with diabetes, compared with placebo.2 Previously, glyburide by itself had not effectively controlled the diabetes in the people in this study.
Ginkgo (Ginkgo biloba)
In a preliminary trial, administration of Ginkgo biloba extract (120 mg per day) for three months to patients with type 2 diabetes who were taking oral anti-diabetes medication resulted in a significant worsening of glucose tolerance. Ginkgo did not impair glucose tolerance in individuals whose diabetes was controlled by diet.3 Individuals taking oral anti-diabetes medication should consult a doctor before taking Ginkgo biloba.
Interactions with Foods and Other Compounds
Food
Glyburide may be taken with food to avoid gastrointestinal (GI) upset.4 Effective treatment of type 2 diabetes with glyburide includes adherence to recommended dietary guidelines.
Alcohol
Alcohol consumption may interfere with blood-sugar control during glyburide therapy.5 Alcohol may interact with glyburide, causing facial flushing, headache, light-headedness, nausea, breathlessness, and other symptoms.6 People taking glyburide should avoid alcohol.
References (To view, roll mouse over the "References" heading; to hide, click on the heading)
1. Anderson RA, Cheng N, Bryden NA, Polansky MM, Cheng N, Chi J, et al. Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes. Diabetes 1997;46:1786–91.
2. Bunyapraphatsara N, Yongchaiyudha S, Rungpitarangsi V, Chokechaijaroenporn O. Antidiabetic activity of Aloe vera L. juice. II. Clinical trial in diabetes mellitus patients in combination with glibenclamide. Phytomed 1996;3:245–8.
3. Kudolo GB. The effect of 3-month ingestion of Ginkgo biloba extract (EGb 761) on pancreatic beta-cell function in response to glucose loading in individuals with non-insulin-dependent diabetes mellitus. J Clin Pharmacol 2001;41:600–11.
4. Threlkeld DS, ed. Hormones, Antidiabetic Agents, Sulfonylureas. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Jun 1992, 130m.
5. Threlkeld DS, ed. Hormones, Antidiabetic Agents, Sulfonylureas. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Jun 1992, 130m.
6. Threlkeld DS, ed. Hormones, Antidiabetic Agents, Sulfonylureas. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Jun 1992, 130m.
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The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2009.