Heath Notes

Hypertension

Also indexed as: Elevated Blood Pressure, High Blood Pressure

Beat hypertension—Lower your blood pressure with simple lifestyle changes to protect yourself from this hidden health problem. According to research or other evidence, the following self-care steps may be helpful:

Sidestep salt
Avoid using too much table salt, limit salty fast foods, and read labels to find low-sodium foods in your grocery store

Watch what you eat
Choose a diet low in cholesterol and animal fat, and high in fruits, vegetables, whole grains, legumes, and low-fat milk products, with some nuts and seeds

Maintain a healthy weight
Lose excess weight and keep it off with a long-term program of exercise and healthier eating

Try CoQ10
Taking 100 mg a day of this powerful antioxidant may have a significant impact on your blood pressure after one to several months

Boost heart health with supplemental garlic
600 to 900 mg a day of a standardized garlic extract can improve heart and blood vessel health, and also has a mild blood pressure–lowering effect

Take minerals
Supplements of calcium (800 to 1,500 mg a day) and magnesium (350 to 500 mg a day) may be helpful

These recommendations are not comprehensive and are not intended to replace the advice of your doctor or pharmacist. Continue reading the full hypertension article for more in-depth, fully-referenced information on medicines, vitamins, herbs, and dietary and lifestyle changes that may be helpful.

About hypertension

Approximately 90% of people with high blood pressure have “essential” or “idiopathic” hypertension, for which the cause is poorly understood. The terms “hypertension” and “high blood pressure” as used here refer only to this most common form and not to pregnancy-induced hypertension or hypertension clearly linked to a known cause, such as Cushing’s syndrome, pheochromocytoma, or kidney disease. Hypertension must always be evaluated by a healthcare professional. Extremely high blood pressure (malignant hypertension) or rapidly worsening hypertension (accelerated hypertension) almost always requires treatment with conventional medicine. People with mild to moderate high blood pressure should work with a doctor before attempting to use the information contained here, as blood pressure requires monitoring and in some cases the use of blood pressure-lowering drugs.

As with conventional drugs, the use of natural substances sometimes controls blood pressure if taken consistently but does not lead to a cure for high blood pressure. Thus, someone whose blood pressure is successfully reduced by weight loss, avoidance of salt, and increased intake of fruits and vegetables would need to maintain these changes permanently in order to retain control of blood pressure. Left untreated, hypertension significantly increases the risk of stroke and heart disease.

Product ratings for hypertension

Science Ratings	Nutritional Supplements	Herbs
	Coenzyme Q10 Fish oil (EPA/DHA) Potassium (for people not taking potassium-sparing diuretics) Soy
	Calcium Fiber Magnesium (for people taking depleting diuretics) Melatonin (for nighttime hypertension) Vitamin D (for deficiency only) Vitamin E	Achillea wilhelmsii Garlic Hawthorn Hibiscus
	Arginine Taurine Vitamin C	Coleus forskohlii European Mistletoe Indian snakeroot Olive leaf Onion Reishi
See also: Homeopathic Remedies for Hypertension
Reliable and relatively consistent scientific data showing a substantial health benefit. Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit. For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support and/or minimal health benefit.

What are the symptoms?

Essential hypertension is usually without symptoms until complications develop. The symptoms of complications depend on the organs involved.

Dietary changes that may be helpful

Primitive societies exposed to very little salt suffer from little or no hypertension.¹ Salt (sodium chloride) intake has also been definitively linked to hypertension in western societies.² Reducing salt intake in the diet lowers blood pressure in most people.³ The more salt is restricted, the greater the blood pressure-lowering effect.⁴ Individual studies sometimes come to differing conclusions about the relationship between salt intake and blood pressure, in part because blood pressure-lowering effects of salt restriction vary from person to person, and small to moderate reductions in salt intake often have minimal effects on blood pressure—particularly in young people and in those who do not have hypertension. Nonetheless, dramatic reductions in salt intake are generally effective for many people with hypertension.

With the prevalence of salted processed and restaurant food, simply avoiding the salt shaker no longer leads to large decreases in salt intake for most people. Totally eliminating salt is more effective, but is quite difficult to achieve. Moreover, while an overview of the research found “There is no evidence that sodium reduction presents any safety hazards,”⁵ reports of short-term paradoxical increases in blood pressure in response to salt restriction have occasionally appeared.⁶ Therefore, people wishing to use salt reduction to lower their blood pressure should consult with a doctor.

Vegetarians have lower blood pressure than do people who eat meat.⁷ This occurs partly because fruits and vegetables contain potassium—a known blood pressure-lowering mineral.⁸ The best way to supplement potassium is with fruit, which contains more of the mineral than do potassium supplements. However, fruit contains so much potassium that people taking “potassium-sparing”diuretics can consume too much potassium simply by eating several pieces of fruit per day. Therefore, people taking potassium-sparing diuretics should consult the prescribing doctor before increasing fruit intake. In the Dietary Approaches to Stop Hypertension (DASH) trial, increasing intake of fruits and vegetables (and therefore fiber) and reducing cholesterol and dairy fat led to large reductions in blood pressure (in medical terms, 11.4 systolic and 5.5 diastolic) in just eight weeks.⁹ Even though it did not employ a vegetarian diet itself, the outcome of the DASH trial supports the usefulness of vegetarian diets because diets employed by DASH researchers were related to what many vegetarians eat. The DASH trial also showed that blood pressure can be significantly reduced in hypertensive people (most dramatically in African Americans) with diet alone, without weight loss or even restriction of salt.¹⁰ Nonetheless, restricting salt while consuming the DASH diet has lowered blood pressure even more effectively than the use of the DASH diet alone.¹¹

Sugar has been reported to increase blood pressure in animals¹² and humans in short-term trials.¹³ Though the real importance of this experimental effect remains unclear,¹⁴ some doctors recommend that people with high blood pressure cut back on their intake of sugar.

Right after consuming caffeine from coffee or tea, blood pressure increases briefly.¹⁵ ¹⁶ In trials lasting almost two months on average, coffee drinking has led to small increases in blood pressure.¹⁷ The effects of long-term avoidance of caffeine (from coffee, tea, chocolate, cola drinks, and some medications) on blood pressure remain unclear. A few reports have even claimed that long-term coffee drinkers tend to have lower blood pressure than those who avoid coffee.¹⁸ Despite the lack of clarity in published research, many doctors tell people with high blood pressure to avoid consumption of caffeine.

Several double-blind trials have shown that adding 6.5–7 grams of fiber per day to the diet for several months leads to reductions in blood pressure.¹⁹ ²⁰ ²¹ However, other trials have not found fiber helpful in reducing blood pressure.²² ²³ The reason for these discrepant findings is not clear.

Food allergy was reported to contribute to high blood pressure in a study of people who had migraine headaches.²⁴ In that report, all 15 people who also had high blood pressure experienced a significant drop in blood pressure when put on a hypoallergenic diet. People who suffer migraine headaches and have hypertension should discuss the issue of allergy diagnosis and elimination with a doctor.

Reusing vegetable oils for frying, especially oils with high concentrations of unsaturated fatty acids (such as sunflower or safflower oil) has been associated with an increased risk of high blood pressure.²⁵ Presumably, this increased risk is due to some of the degradation products (such as lipid peroxides or polymers) that result from the excessive heating of these oils. Frying with more stable oils, such as olive oil, is not associated with an increased risk of high blood pressure.

Exposure to lead and other heavy metals has been linked to high blood pressure in some,²⁶ but not all, research.²⁷ If other approaches to high blood pressure prove unsuccessful, it makes sense for people with hypertension to have their body’s burden of lead evaluated by a healthcare professional.

In a double-blind trial, supplementation with a tomato extract significantly lowered both systolic and diastolic blood pressure, compared with a placebo, in people with hypertension.²⁸ The amount of extract used was 250 mg per day (providing 15 mg per day of lycopene plus other carotenoids) for eight weeks.

Lifestyle changes that may be helpful

Smoking is particularly injurious for people with hypertension.²⁹ The combination of hypertension and smoking greatly increases the risk of heart disease–related sickness and death. All people with high blood pressure need to quit smoking.

Consumption of more than about three alcoholic beverages per day appears to increase blood pressure.³⁰ Whether one or two drinks per day meaningfully increases blood pressure remains unclear.

Daily exercise can lower blood pressure significantly.³¹ A 12-week program of Chinese T’ai Chi was reported to be almost as effective as aerobic exercise in lowering blood pressure.³² Progressive resistance exercise (e.g., weight lifting) also appears to help reduce blood pressure.³³ At the same time, blood pressure has been known to increase significantly during the act of lifting heavy weights; for this reason, people with sharply elevated blood pressure, especially those with cardiovascular disease, should approach heavy strenuous resistance exercise with caution. In general, people over 40 years of age should consult with their doctors before starting any exercise regimen.

Most people with high blood pressure are overweight. Weight loss lowers blood pressure significantly in those who are both overweight and hypertensive.³⁴ In fact, reducing body weight by as little as ten pounds can lead to a significant reduction in blood pressure.³⁵ Weight loss appears to have a stronger blood pressure-lowering effect than dietary salt restriction.³⁶

Other therapies

Healthcare practitioners may also recommend lifestyle modifications, such as moderate weight reduction and a decrease in salt intake. Though essential hypertension has no cure, treatment can modify its course and reduce the risk of complications.

Vitamins that may be helpful

Both preliminary³⁷ ³⁸ ³⁹ and double-blind⁴⁰ ⁴¹ trials have reported that supplementation with Coenzyme Q10 (CoQ10) leads to a significant decrease in blood pressure in people with hypertension. Much of this research has used 100 mg of CoQ10 per day for at least ten weeks.

EPA and DHA, the omega-3 fatty acids found in fish oil, lower blood pressure, according to an analysis of 31 trials.⁴² The effect was dependent on the amount of omega-3 oil used, with the best results occurring in trials using unsustainably high levels: 15 grams per day—the amount often found in 50 grams of fish oil. Although results with lower intakes were not as impressive, trials using over 3 grams per day of omega-3 (as typically found in ten 1,000 mg pills of fish oil) also reported significant reductions in blood pressure. One double-blind trial reported that DHA had greater effects on blood pressure than EPA or mixed fish oil supplements.⁴³ DHA is now available as a supplement separate from EPA.

Potassium supplements in the amount of at least 2,400 mg per day lower blood pressure, according to an analysis of 33 trials.⁴⁴ However, potassium supplements greater than 100 mg per tablet require a prescription, and the low-dose potassium supplements available without a prescription can irritate the stomach if taken in large amounts. Moreover, some people, such as those taking potassium-sparing diuretics, should not take potassium supplements. Therefore, the use of potassium supplements for lowering blood pressure should only be done under the care of a doctor.

Some,⁴⁵ but not all,⁴⁶ trials show that magnesium supplements—typically 350–500 mg per day—lower blood pressure. Magnesium appears to be particularly effective in people who are taking potassium-depleting diuretics.⁴⁷ Potassium-depleting diuretics also deplete magnesium. Therefore, the drop in blood pressure resulting from magnesium supplementation in people taking these drugs may result from overcoming a mild magnesium deficiency.

Calcium supplementation—typically 800–1,500 mg per day—may lower blood pressure. However, while an analysis of 42 trials reported that calcium supplementation led to an average drop in blood pressure that was statistically significant, the actual decrease was small (in medical terms, a drop of 1.4 systolic over 0.8 diastolic pressure).⁴⁸ Results might have been improved had the analysis been limited to studies of people with hypertension, since calcium has almost no effect on the blood pressure of healthy people. In the analysis of 42 trials, effects were seen both with dietary calcium and with use of calcium supplements. A 12-week trial of 1,000 mg per day of calcium accompanied by blood pressure monitoring is a reasonable way to assess efficacy in a given person.

In a double-blind trial, women with low blood levels of vitamin D (measured as 25-hydroxyvitamin D3) were given a calcium supplement, plus either 800 IU of vitamin D per day or a placebo for eight weeks. Compared with the placebo, vitamin D significantly reduced systolic blood pressure by an average of 9.3%, but did not affect diastolic blood pressure.⁴⁹

In a double-blind study, supplementation with 2 mg of sustained-release melatonin each night for four weeks significantly reduced nighttime systolic blood pressure, compared with a placebo, in people with nocturnal hypertension.⁵⁰ Normally, blood pressure declines at night. People with hypertension who do not have this nighttime blood pressure decline are at increased risk of developing and dying from heart disease. Melatonin supplementation may therefore be beneficial for this subgroup of people with hypertension.

In a double-blind study of postmenopausal women, supplementing with 10 grams of soy protein twice a day for six weeks significantly reduced diastolic blood pressure by an average of 5 mm Hg, compared with a diet not containing soy protein.⁵¹ In another study, men and women with mild to moderate hypertension consumed 500 ml (approximately 16 ounces) of soy milk or cow's milk twice a day for three months. After three months, the average systolic blood pressure had decreased by 18.4 mm Hg in the soy group, compared with 1.4 mm Hg in the cow's milk group. The reductions in diastolic blood pressure were 15.9 mm Hg with soy milk and 3.7 mm Hg with cow's milk.⁵² In another study of people with hypertension who were consuming a low-protein, low-fiber diet, supplementing with a combination of soy protein and psyllium (a fiber source) lowered systolic blood pressure by an average of 5.9 mm Hg.⁵³ The blood pressure reduction with soy protein alone or with fiber alone was less pronounced than that with combination treatment. Other research has also shown a blood pressure–lowering effect of soy protein.⁵⁴ ⁵⁵

Five double-blind trials have found that vitamin C supplementation reduces blood pressure, but the reduction was statistically significant in only three of the five, and in most cases reductions were modest.⁵⁶ ⁵⁷ Some doctors recommend that people with elevated blood pressure supplement with 1,000 mg vitamin C per day.

In a double-blind study of people with high blood pressure, 200 IU of vitamin E per day taken for 27 weeks was significantly more effective than a placebo at reducing both systolic and diastolic blood pressure.⁵⁸ This study was done in Iran, and it is not clear whether the results would apply to individuals consuming a Western diet.

A deficiency of the amino acid taurine, is thought by some researchers to play an important role in elevating blood pressure in people with hypertension.⁵⁹ Limited research has found that supplementation with taurine lowers blood pressure in animals⁶⁰ and in people (at 6 grams per day),⁶¹ possibly by reducing levels of the hormone epinephrine (adrenaline).

The amino acid arginine is needed by the body to make nitric oxide, a substance that allows blood vessels to dilate, thus leading to reduced blood pressure. Intravenous administration of arginine has reduced blood pressure in humans in some reports.⁶² In one controlled trial, people not responding to conventional medication for their hypertension were found to respond to a combination of conventional medication and oral arginine (2 grams taken three times per day.)⁶³

Are there any side effects or interactions?
Refer to the individual supplement for information about any side effects or interactions.

Herbs that may be helpful

In a double-blind trial, people with mild hypertension took a tincture of Achillea wilhelmsii, an herb used in traditional Persian medicine.⁶⁴ Participants in the trial used 15–20 drops of the tincture twice daily for six months. At the end of the trial, participants experienced significant reductions in both systolic and diastolic blood pressure compared to those who took placebo. No adverse effects were reported.

Garlic has a mild blood pressure-lowering effect, according to an analysis of ten double-blind trials.⁶⁵ All of these trials administered garlic for at least four weeks, typically using 600–900 mg of garlic extract per day. Onion—closely related to garlic—may also have a mild blood pressure-lowering effect, according to preliminary research.⁶⁶

Two controlled clinical trials have shown that hibiscus can lower blood pressure. In one, people with high blood pressure who went off their medications were given either 2 teaspoons (5 to 6 grams) Hibiscus sabdariffa infused in 1 cup (250 ml) water or black tea three times per day.⁶⁷ After 12 days the hibiscus group had significantly lower blood pressure than the black tea group. In another trial 10 grams of Hibiscus sabdariffa tea was compared to the drug captopril for four weeks in people with high blood pressure.⁶⁸ Blood pressures fell an equal amount in both groups, suggesting this herbal tea may be as potent as some blood pressure medications.

European mistletoe (Viscum album) has reduced headaches and dizziness associated with high blood pressure, according to preliminary research.⁶⁹ Mistletoe may be taken as 0.5 ml tincture three times per day.⁷⁰ The blood pressure-lowering effect of mistletoe is small and may take weeks to become evident. Due to possible serious side effects, European mistletoe should only be taken under the careful supervision of a physician trained in its use.

Indian snakeroot (Rauwolfia serpentina) contains powerful alkaloids, including reserpine, that affect blood pressure and heart function. Indian snakeroot has been used traditionally to treat hypertension, especially when associated with stress and anxiety.⁷¹ Due to possible serious side effects, Indian snakeroot should only be taken under the careful supervision of a physician trained in its use.

In animal studies oleuropein, one of the constituents of olive leaf, has decreased blood pressure and dilated arteries surrounding the heart, when given by injection or intravenously.⁷² Olive leaf has been used traditionally to treat people with hypertension,⁷³ but controlled human trials are needed before a blood pressure-lowering effect can be established.

A double-blind trial reported that reishi mushrooms significantly lowered blood pressure in humans.⁷⁴ The trial used a concentrated extract of reishi (25:1) in the amount of 55 mg three times per day for four weeks. It is unclear from the clinical report how long it takes for the blood pressure-lowering effects of reishi to be measured.

Hawthorn leaf and flower extracts have been reported to have a mild blood pressure–lowering effect in people with early stage congestive heart failure.⁷⁵ In a double-blind study, supplementation with a hawthorn extract significantly decreased diastolic blood pressure in people with type 2 diabetes. The amount used was 1,200 mg per day of an extract standardized to 2.2% flavonoids corresponding to 6 per day of dried flowering tops.⁷⁶

Human trials investigating the use of Coleus forskohlii in blood pressure reduction have yet to be conducted. However, forskolin, the active ingredient in Coleus forskohlii, has lowered blood pressure in a small, preliminary trial with people suffering from cardiomyopathy.⁷⁷ Extracts of coleus standardized to contain 15–20% forskolin are available, but further trials are needed to determine effective levels for treating people with hypertension.

Most herbal reference books suggest that ginseng should not be used by people with hypertension. However, the results of a preliminary trial suggest that red ginseng root (Panax ginseng radix rubra) has either no effect on, or may actually slightly lower, blood pressure in hypertensive people.⁷⁸ However, many herbalists continue to believe that people with hypertension should avoid Asian ginseng and American ginseng, and, while not a true ginseng, Siberian ginseng (eleuthero) as well.

Are there any side effects or interactions?
Refer to the individual herb for information about any side effects or interactions.

Holistic approaches that may be helpful

Anxiety in men (but not women) has been linked to development of hypertension.⁷⁹ Several research groups have also shown a relationship between job strain and high blood pressure in men.⁸⁰ ⁸¹ ⁸² Some researchers have tied blood pressure specifically to suppressed aggression.⁸³

Although some kind of relationship between stress and high blood pressure appears to exist, the effects of treatment for stress remain controversial. An analysis of 26 trials reported that reductions in blood pressure caused by biofeedback or meditation were no greater than those seen with placebo.⁸⁴ Though some stress management interventions have not been helpful in reducing blood pressure,⁸⁵ ⁸⁶ those trials that have reported promising effects have used combinations of yoga, biofeedback, and/or meditation.⁸⁷ ⁸⁸ ⁸⁹ Some doctors continue to recommend a variety of stress-reducing measures, sometimes tailoring them to the needs and preferences of the person seeking help.

Preliminary laboratory studies in animals⁹⁰ and humans⁹¹ ⁹² ⁹³ suggest that acupuncture may help regulate blood pressure. Most,⁹⁴ ⁹⁵ ⁹⁶ ⁹⁷ ⁹⁸ ⁹⁹ but not all,¹⁰⁰ preliminary trials also suggest that acupuncture may be an effective way to lower blood pressure. Whether blood pressure goes back up after acupuncture is discontinued remains an unsettled question.

Auricular (ear) acupressure has been reported to be an effective treatment for hypertension,¹⁰¹ ¹⁰² ¹⁰³ though in one case the improvement was not significantly better than use of traditional herbal medicines.¹⁰⁴

Spinal manipulation may lower blood pressure (at least temporarily) in healthy people, according to most preliminary¹⁰⁵ ¹⁰⁶ ¹⁰⁷ and controlled¹⁰⁸ trials. However, some research suggests the effect is no better than the blood pressure-lowering effect of sham (“fake”) manipulation.¹⁰⁹ In hypertensive people, temporary decreases in blood pressure have also been reported after spinal manipulation.¹¹⁰ ¹¹¹ ¹¹² However, most,¹¹³ ¹¹⁴ ¹¹⁵ but not all,¹¹⁶ trials suggest that manipulation produces only short-term decreases in blood pressure in hypertensive people.

References
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1. Page LB, Damon A, Moellering RC Jr. Antecedents of cardiovascular disease in six Solomon Islands Societies. Circulation 1974;44:1132–46.

2. Stamler J, Rose G, Elliott P, et al. Findings of the international cooperative INTERSALT study. Hypertension 1991;17(1 Suppl):I9–15.

3. MacGregor GA, Markandu ND, Sagnella GA, et al. Double-blind study of three sodium intakes and long-term effects of sodium restriction in essential hypertension. Lancet 1989;2:1244–7.

4. Cutler JA, Follmann D, Allender PS. Randomized trials of sodium reduction: an overview. Am J Clin Nutr 1997;65(Suppl):643S–51S.

5. Cutler JA, Follmann D, Allender PS. Randomized trials of sodium reduction: an overview. Am J Clin Nutr 1997;65(Suppl):643S–51S.

6. Egan BM, Stepniakowski KT. Adverse effects of short-term, very-low-salt diets in subjects with risk-factor clustering. Am J Clin Nutr 1997;65(Suppl):671S–7S.

7. Margetts BM, Beilin LJ, Vandongen R, Armstrong BK. Vegetarian diet in mild hypertension: a randomised controlled trial. BMJ 1986;293:1468–71.

8. Cappuccio FP, MacGregor GA. Does potassium supplementation lower blood pressure? A meta-analysis of published trials. J Hypertens 1991;9:465–73.

9. Appel LJ, Moore TJ, Boarzanek E, et al. A clinical trial of the effects of dietary patterns on blood pressure. N Engl J Med 1997;336:1117–24.

10. Svetkey LP, Simons-Morton D, Vollmer WM, et al. Effects of dietary patterns on blood pressure: a subgroup analysis of the Dietary Approaches to Stop Hypertension (DASH) randomized clinical trial. Arch Intern Med 1999;159:285–93.

11. Sachs FM, Svetkey LP, Vollmer WM, et al. Effects on Blood Pressure of Reduced Dietary Sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. N Engl J Med 2001;344:3–10.

12. Zein M, Areas JL, Breuss GH. Effects of excess sucrose ingestion on the lifespan of SHR. J Am Coll Nutr 1989;8:435 [abstract #42].

13. Rebello T, Hodges RE, Smith JL. Short-term effects of various sugars on antinatriuresis and blood pressure changes in normotensive young men. Am J Clin Nutr 1983;38(1):84–94.

14. Preuss HG, Fournier RD. Effects of sucrose ingestion on blood pressure. Life Sci 1982;30:879–86.

15. Rachima-Maoz C, Peleg E, Rosenthal T. The effect of caffeine on ambulatory blood pressure in hypertensive patients. Am J Hypertens 1998;11:1426–32.

16. Hodgoson JM, Buddey IB, Burke V, et al. Effects on blood pressure of drinking green and black tea. J Hypertens 1999;17:457–63.

17. Jee SH, He J, Whelton PK, et al. The effect of chronic coffee drinking on blood pressure. A meta-analysis of controlled clinical trials. Hypertension 1999;33:647–52.

18. Wakabayashi K, Kono S, Shinchi K, et al. Habitual coffee consumption and blood pressure: a study of self-defense officials in Japan. Eur J Epidemiol 1998;14:669–73.

19. Rossner S, Andersson IL, Ryttig K. Effects of a dietary fibre supplement to a weight reduction programme on blood pressure. A randomized, double-blind, placebo-controlled study. Acta Med Scand 1988;223:353–7.

20. Eliasson K, Ryttig KR, Hylander B, Rossner S. A dietary fibre supplement in the treatment of mild hypertension. A randomized, double-blind, placebo-controlled trial. J Hypertens 1992;10:195–9.

21. Schlamowitz P, Halberg T, Warnoe O, et al. Treatment of mild to moderate hypertension with dietary fibre. Lancet 1987;2:622–3.

22. Fehily AM, Burr ML, Butland BK, Eastham RD. A randomised controlled trial to investigate the effect of a high fibre diet on blood pressure and plasma fibrinogen. J Epidemiol Community Health 1986;40:334–7.

23. Swain JF, Rouse IL, Curley CB, Sacks FM. Comparison of the effects of oat bran and low-fiber wheat on serum lipoprotein levels and blood pressure. N Engl J Med 1990;322:147–52.

24. Grant ECG. Food Allergies and migraine. Lancet 1979;1:966–9.

25. Soriguer F, Rojo-Martinez G, Dobarganes MC, et al. Hypertension is related to the degradation of dietary frying oils. Am J Clin Nutr 2003;78:1092–7.

26. Pirkle JL, Schwartz H, Landis JR, et al. The relationship between blood lead levels and blood pressure and its cardiovascular risk implications. Am J Epidemiol 1985;121(2):246–58.

27. Wu TN, Shen CY, Ko KN, et al. Occupational lead exposure and blood pressure. Int J Epidemiol 1996;25:791–6.

28. Engelhard YN, Gazer B, Paran E. Natural antioxidants from tomato extract reduce blood pressure in patients with grade-1 hypertension: a double-blind, placebo-controlled pilot study. Am Heart J 2006;151:100.

29. Narkiewicz K, Maraglino G, Biasion T, et al. Interactive effect of cigarettes and coffee on daytime systolic blood pressure in patients with mild essential hypertension. J Hypertens 1995;13:965–70.

30. Keil U, Liese A, Filipiak B, et al. Alcohol, blood pressure and hypertension. Novartis Round Symp 1998;216:125–44 [review].

31. Kukkonen K, Rauramaa R, Voutilainene E, Lansimies E. Physical training of middle-aged men with borderline hypertension. Ann Clin Res 1982;14(Suppl 34):139–45.

32. Young DR, Appel LG, Jee SH, Miller ER III. The effect of aerobic exercise and T’ai Chi on blood pressure in older people: results of a randomized trial. J Am Geriatr Soc 1999;47:277–84.

33. Kelley GA, Kelley KS. Progressive resistance exercise and resting blood pressure. A meta-analysis of randomized controlled trials. Hypertension 2000;35:838–43.

34. Alderman MH. Nonpharmacologic approaches to the treatment of hypertension. Lancet 1994;334:307–11 [review].

35. Stevens VJ, Obarzanek E, Cook NR, et al. Long-term weight loss and changes in blood pressure: results of the Trials of Hypertension Prevention, Phase II. Ann Intern Med 2001;134:1–11.

36. He J, Whelton PK, Appel LJ, et al. Long-term effects of weight loss and dietary sodium reduction on incidence of hypertension. Hypertension 2000;35:544–9.

37. Folkers K, Drzewoski J, Richardson PC, et al. Bioenergetics in clinical medicine. XVI. Reduction of hypertension in patients by therapy with coenzyme Q10. Res Commun Chem Pathol Pharmacol 1981;31:129–40.

38. Langsjoen P, Langsjoen P, Willis R, Folkers K. Treatment of essential hypertension with coenzyme Q10. Mol Aspects Med 1994;15 Suppl:s265–72.

39. Digiesi V, Cantini F, Oradei A, et al. Coenzyme Q10 in essential hypertension. Molec Aspects Med 1994;15 Suppl:s257–63.

40. Digiesi V, Cantini F, Brodbeck B. Effect of coenzyme Q10 on essential arterial hypertension. Curr Ther Res 1990;47:841–5.

41. Singh RB, Niaz MA, Rastogi SS, et al. Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease. J Hum Hypertens 1999;13:203–8.

42. Morris MC, Sacks F, Rosner B. Does fish oil lower blood pressure? A meta-analysis of controlled trials. Circulation 1993;88:523–33.

43. Mori TA, Bao DQ, Burke V, et al. Docosahexaenoic acid but not eicosapentaenoic acid lowers ambulatory blood pressure and heart rate in humans. Hypertension 1999;34:253–60.

44. Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure: meta-analysis of randomized controlled clinical trials. JAMA 1997;277:1624–32.

45. Motoyama T, Sano H, Fukuzaki H, et al. Oral magnesium supplementation in patients with essential hypertension. Hypertension 1989;13:227–32.

46. Patki PS, Singh J, Gokhale SV, et al. Efficacy of potassium and magnesium in essential hypertension: a double-blind, placebo controlled, crossover study. BMJ 1990;301:521–3.

47. Dyckner T, Wester PO. Effect of magnesium on blood pressure. BMJ 1983;286:1847–9.

48. Griffith LE, Guyatt GH, Cook RJ, et al. The influence of dietary and nondietary calcium supplementation on blood pressure. An updated metaanalysis of randomized controlled trials. Am J Hypertens 1999;12:84–92.

49. Pfeifer M, Begerow B, Minne HW, et al. Effects of a short-term vitamin D3 and calcium supplementation on blood pressure and parathyroid hormone levels in elderly women. J Clin Endocrinol Metab 2001;86:1633–7.

50. Grossman E, Laudon M, Yalcin R, et al. Melatonin reduces night blood pressure in patients with nocturnal hypertension. Am J Med 2006;119:898–902.

51. Washburn S, Burke GL, Morgan T, Anthony M. Effect of soy protein supplementation on serum lipoproteins, blood pressure, and menopausal symptoms in perimenopausal women. Menopause 1999;6:7–13.

52. Rivas M, Garay RP, Escanero JF, et al. Soy milk lowers blood pressure in men and women with mild to moderate essential hypertension. J Nutr 2002;132:1900–2.

53. Burke V, Hodgson JM, Beilin LJ, et al. Dietary protein and soluble fiber reduce ambulatory blood pressure in treated hypertensives. Hypertension 2001;38:821–6.

54. He J, Gu D, Wu X, et al. Effect of soybean protein on blood pressure: a randomized, controlled trial. Ann Intern Med 2005;143:1–9.

55. Welty FK, Lee KS, Lew NS, Zhou JR. Effect of soy nuts on blood pressure and lipid levels in hypertensive, prehypertensive, and normotensive postmenopausal women. Arch Intern Med 2007;167:1060–7.

56. Ness AR, Chee D, Elliott P. Vitamin C and blood pressure—an overview. J Human Hypertens 1997;11:343–50.

57. Fotherby MD, Williams JC, Forster LA, et al. Effect of vitamin C on ambulatory blood pressure and plasma lipids in older persons. J Hypertens 2000;18:411–5.

58. Boshtam M, Rafiei M, Sadeghi K, Sarraf-Zadegan N. Vitamin E can reduce blood pressure in mild hypertensives. Int J Vitam Nutr Res 2002;72:309–14.

59. Kohashi N, Katori R. Decrease of urinary taurine in essential hypertension. Jpn Heart J 1983;24:91–102.

60. Abe M, Shibata K, Matsuda T, Furukawa T. Inhibition of hypertension and salt intake by oral taurine treatment in hypertensive rats. Hypertension 1987;10:383–9.

61. Fujita T, Ando K, Noda H, et al. Effects of increased adrenomedullary activity and taurine in young patients with borderline hypertension. Circulation 1987;75:525–32.

62. Calver A, Collier J, Vallance P. Dilator actions of arginine in human peripheral vasculature. Clin Sci 1991;81:695–700.

63. Pezza V, Bernardini F, Pezza E, et al. Study of supplemental oral l-arginine in hypertensives treated with enalapril + hydrochlorothiazide. Am J Hypertens 1998;11:1267–70 [letter].

64. Asgary S, Naderi GH, Sarrafzadegan N, et al. Antihypertensive and antihyperlipidemic effects of Achillea wilhelmsii. Drugs Exp Clin Res 2000;26:89–93.

65. Silagy C, Neil AW. A meta-analysis of the effect of garlic on blood pressure. J Hypertension 1994;12:463–8.

66. Louria DB, McAnally JF, Lasser N, et al. Onion extract in treatment of hypertension and hyperlipidemia: A preliminary communication. Curr Ther Res 1985;37:127–31.

67. (REF:Haji Faraji M, Haji Tarkhani AH. The effect of sour tea (Hibiscus sabdariffa) on essential hypertension. J Ethnopharmacol 1999;65:231–6.

68. Herrera-Arellano A, Flores-Romero S, Chavez-Soto MA, Tortoriello J. Effectiveness and tolerability of a standardized extract from Hibiscus sabdariffa in patients with mild to moderate hypertension: a controlled and randomized clinical trial. Phytomedicine 2004;11(5):375–82.

69. Bowman IA. The everlasting mistletoe and the cardiovascular system. Texas Heart Inst J 1990;17(4):310–4 [review].

70. British Herbal Medicine Association. British Herbal Pharmacopoeia. West Yorks, UK: BHMA, 1983.

71. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. American Botanical Council, Austin, TX. Integrative Medical Communications, Boston, MA: 1998, 152–3.

72. Petkov V, Manolov P. Pharmacological analysis of the iridoid oleuropein. Arzneimittelforschung 1972;22:1476–86.

73. Weiss RF. Herbal Medicine. Gothenburg, Sweden: AB Arcancum, 1988, 160–1.

74. Jin H, Zhang G, Cao X, et al. Treatment of hypertension by ling zhi combined with hypotensor and its effects on arterial, arteriolar and capillary pressure and microcirculation. In: Nimmi H, Xiu RJ, Sawada T, Zheng C (eds). Microcirculatory Approach to Asian Traditional Medicine. New York: Elsevier Science, 1996, 131–8.

75. Schmidt U, Kuhn U, Ploch M, Hübner W-D. Efficacy of the hawthorn (Crataegus) preparation LI 132 in 78 patients with chronic congestive heart failure defined as NYHA functional class II. Phytomed 1994;1(1):17–24.

76. Walker AF, Marakis G, Simpson E, et al. Hypotensive effects of hawthorn for patients with diabetes taking prescription drugs: a randomised controlled trial. Br J Gen Pract 2006;56:437–43.

77. Kramer W, Thormann J, Kindler M, Schlepper M. Effects of forskolin on left ventricular function in dilated cardiomyopathy. Arzneimittelforschung 1987;37:364–7.

78. Han KH, Choe SC, Kim HS, et al. Effect of red ginseng on blood pressure in patients with essential hypertension and white coat hypertension. Am J Chin Med 1998;26:199–209.

79. Markovitz JH, Matthews KA, Kannel WB, et al. Psychological predictors of hypertension in the Framingham Study. Is there tension in hypertension?JAMA 1993;270:2439–43.

80. Schnall PL, Schwartz JE, Landesbergis PA, et al. Relation between job strain, alcohol, and ambulatory blood pressure. Hypertension 1992;19:488–94.

81. Matthews KA, Cottington EM, Talbott E, et al. Stressful work conditions and diastolic blood pressure among blue collar factory workers. Am J Epidemiol 1987;126:280–91.

82. Pickering TG. Does psychological stress contribute to the development of hypertension and coronary heart disease? Eur J Clin Pharmacol 1990;39(Suppl 1):S1–S7.

83. Perini C, Müller FB, Bühler FR. Suppressed aggression accelerates early development of essential hypertension. J Hypertens 1991;9:499–503.

84. Eisenberg DM, Delbanco TL, Berkey CS, et al. Cognitive behavioral techniques for hypertension: are they effective? Ann Intern Med 1993;118:964–72.

85. Irvine MJ, Logan AG. Relaxation behavior therapy as sole treatment for mild hypertension. Psychosomatic Med 1991;53:587–97.

86. Johnston DW, Gold A, Kentish J, et al. Effect of stress management on blood pressure in mild primary hypertension. BMJ 1993;306:963–6.

87. Patel CH. Yoga and bio-feedback in the management of hypertension. Lancet 1973;2:1973–5.

88. Schneider RH, Staggers F, Alexander C, et al. A randomized controlled trial of stress reduction for hypertension in older African Americans. Hypertension 1995;26:820–9.

89. Patel C, Marmot MG, Terry DJ, et al. Trial of relaxation in reducing coronary risk: four year follow up. BMJ 1985;290:1103–6.

90. Lee HS, Kim JY. Effects of acupuncture on blood pressure and plasma renin activity in two-kidney one clip goldblatt hypertensive rats. Am J Chin Med 1994;22:215–9.

91. Chiu YJ, Chi A, Reid IA. Cardiovascular and endocrine effects of acupuncture in hypertensive patients. Clin Exper Hypertens 1997;19:1047–63.

92. Peng L, Feng-yen S, An-zhong Z. The effect of acupuncture on blood pressure: the interrelation of sympathetic activity and endogenous opioid peptides. Acupunct Electrother Res 1983;8:45–56.

93. Zhou Y, Wang Y, Fang Z, et al. Influence of acupuncture on blood pressure, contents of NE, DA and 5-HT of SHR and the interrelation between blood pressure and whole blood viscosity. Chen Tzu Yen Chiu 1995;20:55–61 [in Chinese].

94. Radzievsky SA, Lebedeva OD, Fisenko LA, Majskaja SA. Function of myocardial contraction and relaxation in essential hypertension in dynamics of acupuncture therapy. Am J Chin Med 1989;17:111–7.

95. Williams T, Mueller K, Cornwall MW. Effect of acupuncture-point stimulation on diastolic blood pressure in hypertensive subjects: a preliminary study. Phys Ther 1991;71:523–9.

96. Weihai Y, Hongxu L. Clinical observation on the immediate hypotensive effect of zanzhu point. J Tradit Chin Med 1996;16:273–4.

97. Utsunomiya N, Shigematsu Y, Ikeda K, et al. Fall in high blood pressure after applying acupuncture to SHR. Jpn Heart J 1978;19:594.

98. Yiping Z, Qiong C, Zhengming H, Yinong C. Experimental research on treatment of hypertension with acupuncture. J Tradit Chin Med 1993;13:277–80.

99. Tam K-C, Yiu H-H. The effect of acupuncture on essential hypertension. Am J Chin Med 1975;3:369–75.

100. Kraft K, Coulon S. Effect of a standardized acupuncture treatment on complains, blood pressure and serum lipids of hypertensive, postmenopausal women. A randomized, controlled clinical study. Forsch Komplementarmed 1999;6:74–9 [in German].

101. Rongxing Z, Yanhua Z, Lu Y. Hypotensive effect of ototherapy in relation to symptomatic and dispositional types of patients. J Tradit Chin Med 1992;12:124–8.

102. Kangmei C, Shulian Z, Ying Z. Clinical application of traditional auriculoacupoint therapy (continued). J Tradit Chin Med 1993;13:152–4.

103. Rongxing Z, Yanhua Z, Jialiang W, et al. Anti-hypertensive effect of auriculo-acupoint pressing therapy—clinical analysis of 274 cases. J Tradit Chin Med 1991;11:189–92.

104. Peng Y, Fenglan L, Xin W. Treatment of essential hypertension with auriculopressure. J Tradit Chin Med 1991;1117–21.

105. Tran T, Kirby J. Effects of upper cervical adjustments upon the normal physiology of the heart. ACA J Chiro 1977;XI:S58–62.

106. McGuiness J, Vicenzino B, Wright A. The influence of a cervical mobilization technique on respiratory and cardiovascular function. Manual Therapy 1997;(2):216–20.

107. Vicenzino B, Cartwright T, Collins D. Cardiovascular and respiratory changes produced by lateral glide mobilization of the cervical spine Manual Therapy 1998;3(2):67–71.

108. Dulgar G, Hill D, Sirucek A, et al. Evidence for possible anti-hypertensive effect of basic technique apex contact adjusting. J Chiro 1980;14:S97–S102.

109. Nansel D, Jansen R, Cremata E, et al. Effects of cervical adjustments on lateral-flexion passive end-range asymmetry and on blood pressure, heart rate and plasma catecholamine levels. J Manipulative Physiol Ther 1991;14:450–6.

110. Fichera AP, Celander DR. Effect of osteopathic manipulative therapy on autonomic tone as evidenced by blood pressure change and activity of the fibrinolytic system. J Am Osteopath Assoc 1969;68:1036–8.

111. McKnight M, DeBoer KD. Preliminary study of blood pressure changes in normotensive patients under chiropractic care. J Manipulative Physiol Ther 1988;11:261–6.

112. Yates RG, Lamping DL, Nancy LA, Wright C. Effects of chiropractic treatment on blood pressure and anxiety: a randomized, controlled trial. J Manipulative Physiol Ther 1988;11:484–8.

113. Morgan JP, Dickey JL, Hunt HH, Hudgins PM. A controlled trial of spinal manipulation in the management of hypertension. J Am Osteopath Assoc 1985;85(5):308–12.

114. Mannino J. The application of neurologic reflexes to the treatment of hypertension. J Am Osteopath Assoc 1979;79:225–31.

115. Wagnon RJ, Sandefur RM, Ratliff CR. Serum aldosterone changes after specific chiropractic manipulation. Am J Chiropr Med 1988;1(2):66–70.

116. Goodman R. Hypertension and the atlas subluxation complex. Chiropractic: J Chiropractic Res Clin Invest 1992;8(2)30–2.

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The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires September 2008.

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