Amino acids are much more than passive building blocks for protein. Many have specific and important functions of their own. The amino acid glutamine is a great example.
Your body's most important fuel source is glucose (blood sugar), which you get from the sugars and starches (carbohydrate) in your diet. Your body does everything in its power to preserve its glucose supply. But when glucose is in short supply your body can also make it from certain amino acids like glutamine (Nurjhan et al., 1995; Stumvoll et al., 1999).
So as you eat less carbohydrate you convert more glutamine into glucose. This process requires energy, which in this case comes from burning fat. This is at least part of the reason why glutamine supplementation can stimulate the metabolic (calorie-burning) rate in healthy humans (Hankard et al., 1996).
Being an important source of glucose, glutamine may be especially valuable if you are following a carb-restricted diet. Intense workouts lower muscle and liver glycogen contents (glycogen is the storage form of glucose). After working out, your body relies heavily on glutamine to replenish glycogen (Bowtell et al., 1999).
Five to eight grams of L-glutamine consumed post-workout seems to be effective in accelerating glycogen recovery (Bowtell et al., 1999). Make sure your protein powder or meal replacement has a few grams of glutamine in each serving (or add L-glutamine to them) if you want to 'swell' your muscles up with glycogen faster than normal after training.
Glutamine is also a key nutrient for immune health because it is the preferred fuel source for many types of immune cells. It's also used for energy and maintenance by intestinal cells and helps the body maintain proper pH levels.
Selected Sources
- Bowtell JL, Gelly K, Jackman ML, Patel A, Simeoni M, Rennie MJ (1999). Effect of oral glutamine on whole body carbohydrate storage during recovery from exhaustive exercise. J Appl Physiol, 86: 1770.
- Hankard RG, Haymond MW, Darmaun D (1996). Effect of glutamine on leucine metabolism in humans. Am J Physiol, 271: E748.
- Nurjhan N, Bucci A, Periello G et al. (1995). Glutamine: a major gluconeogenic precursor and vehicle for interorgan carbon transport in man. J Clin Invest, 95: 272.
- Stumvoll M, Perriello G, Meyer C, Gerich J (1999). Role for glutamine in human carbohydrate metabolism in kidney and other tissues. Kidney Int, 55: 778.