As we age, we lose muscle mass, which results in muscle weakness and physical limitations. Aging causes mitochondrial dysfunction (cell energy centers) and loss of functional motor units (nerve and muscle cells). Over time, muscle cells continue to lose the ability to repair damage and muscle function deteriorates. Researchers from the Department of Pediatrics and Medicine at McMaster University in Hamilton, Ontario found creatine monohydrate enhanced fat-free mass and strength gains. A more recent study showed the addition of conjugated linoleic acid (CLA) lead to a significant reduction in body weight after six months of resistance training. Their findings suggest that the combination of creatine and CLA with resistance training can generate satellite cells that have the characteristics of young muscle. These satellite cells integrate into old muscle, reversing the effects of aging. They believe future studies are warranted to determine whether the changes can be maintained over a longer period of time.