In one study, 67 people with type 2 diabetes and neuropathy took a placebo or one of two sets of supplements. The first group took 20 mg of zinc, 250 mg of magnesium, 200 mg of vitamin C, and 150 IU of vitamin E per day. The second group took the same supplements plus 10 mg each of vitamins B1, B2 and B6, plus 200 mcg of biotin, 10 mcg of vitamin B12 and 1 mg of folic acid.
After four months, the two supplement groups reported less-severe symptoms than the placebo group. Although doctors said the difference between the placebo and supplement groups was small, they concluded that micronutrients may help relieve diabetic neuropathy.