Weight loss and low body mass because of an underlying illness have been associated with increased mortality, reduced ability to function and diminished quality of life. Several studies have pointed to creatine supplementation as a low-cost, well-tolerated nutritional strategy to offset muscle wasting.
A review of medical literature has shown that creatine can increase muscle mass and performance in those with diseases that affect muscle size and function. While the mechanism isn’t clear, creatine may increase intramuscular phosphocreatine stores and speed recovery of ATP (adenosine triphosphate) levels after exercise, thus allowing longer periods of exercise. It may also reduce inflammation and stimulate satellite cell formation, which is important for muscle growth.