After 12 weeks, while there was no significant change in the placebo or 60 mg groups, those who took 150 mg of CoQ10 had 29 percent lower levels of oxidative stress and a large increase in protective antioxidant enzyme activity.
Doctors concluded CoQ10 may promote rapid and sustainable antioxidation in CAD.
In another study, researchers compared levels of cholesterol, oxidative stress and inflammation in 91 people with advanced coronary artery disease (CAD) to 49 healthy people. Compared to healthy participants, those with CAD had elevated levels of all signs of inflammation, had much lower levels of HDL—the “good” cholesterol—and had lower levels of beta-carotene.
Researchers found that the lower the level of beta-carotene, the higher the level of interleukin-6, a pro-inflammatory molecule released by blood vessels under stress. Doctors said the relationship they found between low levels of beta-carotene and high levels of inflammation suggests that beta-carotene may protect against CAD and other vascular diseases by inhibiting inflammation. Beta-carotene is a powerful antioxidant found in the bright pigment of fruits and vegetables.