In prior lab studies, curcumin showed anti-cancer activity, and doctors wanted to find the best dose to combine with chemotherapy. In a safety study, 14 women with advanced or metastatic breast cancer took oral doses of curcumin four days before and two days after a six-day regimen of chemotherapy with Docetaxel. Doses ranged from 500 mg to 8,000 mg of curcumin. Signs of tumors decreased in seven women, and the disease did not progress in any of the women. The next study is testing a higher dose of 6,000 mg.