In one study, 26 untrained healthy men, aged 20 to 36, took 4,000 mg of L-leucine per day or a placebo. Twice per week during the study, professional trainers supervised the men in eight standard resistance-training machine exercises. Researchers tested strength before and after the study, measuring the maximum weight each participant could resist in five machine repetitions.
After 12 weeks, the placebo group had increased its maximum five-repetition weight resistance ability by 31 percent while the leucine group increased its ability by 41 percent.