Pycnogenol, an extract of pine bark, reduced symptoms of endometriosis, a painful condition where tissue that normally lines the uterus grows outside it, jeopardizing fertility. The study included 58 women, aged 21 to 38, who had undergone an endometriosis operation up to six months prior. All participants were menstruating and ovulating normally in the three months just before the study. Half the women took 30 mg of Pycnogenol twice per day for 48 weeks, while the other half got hormone injections (leuprorelin acetate) for 24 weeks. Symptoms slowly but steadily decreased in the Pycnogenol group. Symptoms declined more in the hormone group at 24 weeks, but had begun to recur by 24 weeks after hormone therapy. Hormone therapy suppressed menstruation during the treatment period, while Pycnogenol did not, leading researchers to conclude that Pycnogenol is a therapeutic alternative to hormone therapy in endometriosis.
Reference: Journal of Reproductive Medicine; 2007, Vol. 52, No. 8, 703-8.